Pinnacle Medicine & Medical Sciences

(ISSN: 2360-9516)

May 2014, Vol.1 (2).

© Author(s) 2014. This work is distributed under the Creative Commons Attribution 3.0 License.

Research Article

 

THE GABAA RECEPTOR AND THE NEUROPHARMACOLOGICAL PROPERTIES OF 1,5-BENZODIAZEPINES OF MEDICINAL INTEREST: A REVIEW

Edeildo Ferreira da Silva Júnior1, Daniel Lira da Silva2, Thiago Mendonça de Aquino2, Êurica Adélia Nogueira Ribeiro1, Nadia Stefania Jelvez Serra2 & João Xavier de Araújo Júnior1

1School of Nursing and Pharmacy,
Post Graduate Program in Pharmaceutical Sciences,
Federal University of Alagoas,
Maceio, Brazil.

2Institute of Chemistry and Biotechnology,
Federal University of Alagoas,
Maceio, Brazil.

Accepted 26 April, 2014; Available Online 8 May, 2014

Abstract:

This article reviews how GABAA receptors act within the neuronal system, focusing on the neuropharmacological properties of some 1,5-benzodiazepines. They are generally involved in various physiological processes, such as brain excitability control, anxiety modulation, hunger sensation, thirst, circadian rhythm, cognition, alertness, memory and learning. The 1,5-benzodiazepines of medical interest differ from others benzodiazepines, as 1,4-benzodiazepines, traditionally used in clinical psychiatry, in nitrogen positions in aromatic ring. They are commonly obtained by condensation reactions between ortho-diaminoerenes and 1,3-diketones, with sulphuric acid as reaction catalyst. Several of these drugs have shown promising results and have the potential to either replace or act as alternatives to 1,4-benzodiazepines.




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